Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism

Chem Commun (Camb). 2011 Aug 14;47(30):8647-9. doi: 10.1039/c1cc12495a. Epub 2011 Jul 1.

Abstract

A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / toxicity
  • Camptothecin / chemistry*
  • Camptothecin / toxicity
  • Glutathione / chemistry
  • Hep G2 Cells
  • Humans
  • Micelles*
  • Nanostructures / chemistry*
  • Oxidation-Reduction
  • Polyethylene Glycols / chemistry
  • Prodrugs / chemistry*
  • Prodrugs / toxicity

Substances

  • Antineoplastic Agents, Phytogenic
  • Micelles
  • Prodrugs
  • Polyethylene Glycols
  • Glutathione
  • Camptothecin