Abstract
A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.
This journal is © The Royal Society of Chemistry 2011
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry*
-
Antineoplastic Agents, Phytogenic / toxicity
-
Camptothecin / chemistry*
-
Camptothecin / toxicity
-
Glutathione / chemistry
-
Hep G2 Cells
-
Humans
-
Micelles*
-
Nanostructures / chemistry*
-
Oxidation-Reduction
-
Polyethylene Glycols / chemistry
-
Prodrugs / chemistry*
-
Prodrugs / toxicity
Substances
-
Antineoplastic Agents, Phytogenic
-
Micelles
-
Prodrugs
-
Polyethylene Glycols
-
Glutathione
-
Camptothecin