Osteolytic mandible presenting as an initial manifestation of an adult acute lymphoblastic leukaemia

Int J Oral Maxillofac Surg. 2011 Dec;40(12):1438-40. doi: 10.1016/j.ijom.2011.01.013. Epub 2011 Jul 1.

Abstract

A case of adult acute lymphoblastic leukaemia is reported. A 35-year-old male presented with an osteolytic lesion of the mandible. There was no definitive involvement in other craniofacial bones. A panoramic radiograph taken 4 months previously showed no bony involvement. A complete blood count showed a slightly decreased red blood cell count, but normal white blood cell count, white blood cell differential count and platelet count. Routine chemistry revealed hypercalcemia with an increased level of parathyroid hormone-related protein. Histopathological examination of bone marrow biopsy confirmed the diagnosis of acute lymphoblastic leukaemia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alveolar Bone Loss / diagnosis
  • Diagnosis, Differential
  • Fatal Outcome
  • Humans
  • Hypercalcemia / diagnosis
  • Male
  • Mandibular Diseases / diagnosis*
  • Multimodal Imaging
  • Osteolysis / diagnosis*
  • Parathyroid Hormone-Related Protein / blood
  • Positron-Emission Tomography
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Radiography, Panoramic
  • Tomography, X-Ray Computed

Substances

  • Parathyroid Hormone-Related Protein