Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4520-3. doi: 10.1016/j.bmcl.2011.05.117. Epub 2011 Jun 12.

Abstract

Sulfuretin is one of major constituents of Rhus verniciflua that exerts anti-inflammatory activities. Some of aurones were synthesized as sulfuretin derivatives and evaluated for their abilities to inhibit NO and PGE(2) production in LPS-induced RAW 264.7 cells in order to reveal the relationship. Of the aurones synthesized in the present study, 2h and 2i, which possess C-6 hydroxyl group in A-ring and methoxy substituents in B-ring, more potently inhibited NO and PGE(2) production and were less cytotoxic than sulfuretin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / toxicity
  • Benzofurans / chemical synthesis
  • Benzofurans / chemistry*
  • Benzofurans / toxicity
  • Cell Line, Tumor
  • Dinoprostone / metabolism*
  • Lipopolysaccharides / toxicity
  • Mice
  • Nitric Oxide / metabolism*

Substances

  • Anti-Infective Agents
  • Benzofurans
  • Lipopolysaccharides
  • aurone
  • Nitric Oxide
  • Dinoprostone