N-[18F]fluoro-N-alkylsulfonamides: novel reagents for mild and regioselective radiofluorination

Int J Rad Appl Instrum A. 1990;41(8):733-8. doi: 10.1016/0883-2889(90)90020-h.

Abstract

N-[18F]fluoro-N-alkylsulfonamides were synthesized by the fluorination of secondary sulfonamides with [18F]F2. Radiochemical yields up to 45% (out of a maximum possible yield of 50%) for these reactions have been realized. The N-[18F]fluorosulfonamides rapidly and regiospecifically fluorinate a variety of Grignard reagents and aryllithium under very mild conditions to give 18F-labeled derivatives in good yields.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Fluorine Radioisotopes*
  • Fluorine*
  • Indicators and Reagents / chemical synthesis
  • Isotope Labeling / methods
  • Sulfonamides / chemical synthesis*

Substances

  • Fluorine Radioisotopes
  • Indicators and Reagents
  • Sulfonamides
  • Fluorine