This case study has two aims. First, it describes intervention strategies from two school-based programs designed to prevent tobacco use among adolescents in India. Second, it explains how evidence from randomized controlled trials of these intervention programs was used by a local non-governmental organization in Delhi to advocate for scaling up the Government of India's tobacco control efforts to include school health interventions as one of the components of India's National Tobacco Control Program. This case study illustrates the need for developing countries to conduct rigorous evaluation in order to provide context-relevant evidence prior to scaling up interventions.