New prenylated C₆-C₃ compounds from the twigs of Illicium anisatum

Chem Pharm Bull (Tokyo). 2011;59(7):898-901. doi: 10.1248/cpb.59.898.

Abstract

Two new prenylated C₆-C₃ compounds, cycloillicinone (1) and 4-allyl-2-methoxy-6-(2-methylbut-3-en-2-yl)phenol (2), were isolated from the twigs of Illicium anisatum, and their structures were determined by 2D-NMR methods. Cycloillicinone (1) is a unique prenylated C₆-C₃ that is appended with an additional geranyl unit. Compound 2 was found to show moderate neurite-outgrowth promoting activity in primary cultured rat cortical neurons at a concentration of 10 µM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Illicium / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Neurons / cytology
  • Neurons / drug effects
  • Phenols / chemistry*
  • Phenols / isolation & purification
  • Phenols / pharmacology
  • Rats
  • Terpenes / chemistry*
  • Terpenes / isolation & purification
  • Terpenes / pharmacology

Substances

  • 4-allyl-2-methoxy-6-(2-methylbut-3-en-2-yl)phenol
  • Phenols
  • Terpenes
  • cycloillicinone