Abstract
Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC₅₀, 0.9, 21.7, and >50.0 µM, respectively, 2: IC₅₀ >50.0, 15.7, and 12.4 µM, respectively).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Annonaceae / chemistry*
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Aporphines / chemistry*
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Aporphines / isolation & purification
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Aporphines / pharmacology
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Plant Bark / chemistry
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Plant Stems / chemistry
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Aporphines
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pseuduvarine A
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pseuduvarine B