Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility

Head Neck. 2012 Apr;34(4):551-6. doi: 10.1002/hed.21779. Epub 2011 Jun 29.

Abstract

Background: The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer.

Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer.

Results: Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote.

Conclusion: The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Case-Control Studies
  • Confidence Intervals
  • DNA, Neoplasm / analysis
  • Female
  • Genetic Predisposition to Disease / epidemiology*
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Middle Aged
  • Mouth Neoplasms / epidemiology*
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / pathology
  • Mouth Neoplasms / physiopathology
  • Multivariate Analysis
  • Odds Ratio
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length
  • Prognosis
  • Receptors, Interleukin / genetics*
  • Retrospective Studies
  • Risk Factors
  • Sex Distribution
  • Taiwan / epidemiology

Substances

  • DNA, Neoplasm
  • IL23R protein, human
  • Receptors, Interleukin