Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes

Chem Commun (Camb). 2011 Aug 14;47(30):8524-6. doi: 10.1039/c1cc12805a. Epub 2011 Jun 30.

Abstract

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Circular Dichroism
  • Electron Spin Resonance Spectroscopy
  • G-Quadruplexes*
  • Guanine / chemistry*
  • Kinetics
  • Nucleic Acid Conformation
  • Nucleosides / chemistry
  • Peptide Nucleic Acids / chemistry*
  • Phase Transition

Substances

  • Nucleosides
  • Peptide Nucleic Acids
  • Guanine