Mouth human populated set of microorganisms that are in dynamic equilibrium and forming microbiocaenosis. In a situation where this balance is disturbed, there is a "activation" of pathogens, including those that lead to the development of inflammatory periodontal diseases. Quantifying the relation parodontopatogenov in this material may be an important diagnostic tool, but data on the profile of individual microbiota subbiotopov mouth so far very little. In this study, we quantified the six pathogenic representatives of the periodontal pocket microbiota in health and periodontitis. Found that when disease development relationship pathogenic representatives of periodontal pocket microbiota varies considerably.