Electrospinning of collagen nanofiber scaffolds from benign solvents

Bin Dong; Olivier Arnoult; Meghan E Smith; Gary E Wnek

doi:10.1002/marc.200800634

Electrospinning of collagen nanofiber scaffolds from benign solvents

Macromol Rapid Commun. 2009 Apr 1;30(7):539-42. doi: 10.1002/marc.200800634. Epub 2009 Feb 5.

Authors

Bin Dong¹, Olivier Arnoult, Meghan E Smith, Gary E Wnek

Affiliation

¹ Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.

PMID: 21706638
DOI: 10.1002/marc.200800634

Abstract

Nanofiber scaffolds of collagen have been fabricated via electrospinning using benign solvent systems as a replacement for 1,1,1,3,3,3 hexafluoro-2-propanol. Simple binary mixtures of phosphate-buffered saline and ethanol have been found to be highly effective for electrospinning. FTIR spectra suggest that the triple helical structure of collagen was conserved after dissolution and electrospinning. Crosslinking of the electrospun collagen scaffolds was achieved with standard methods.