Relationship between cAMP concentration in anterior hypothalamic-preoptic region and the ultradian wake-sleep cycle

R Amici; L Fadiga; E Perez; G Zamboni; P L Parmeggiani

doi:10.1016/0165-1838(90)90092-w

Relationship between cAMP concentration in anterior hypothalamic-preoptic region and the ultradian wake-sleep cycle

J Auton Nerv Syst. 1990 Jul:30 Suppl:S5-7. doi: 10.1016/0165-1838(90)90092-w.

Authors

R Amici¹, L Fadiga, E Perez, G Zamboni, P L Parmeggiani

Affiliation

¹ Istituto di Fisiologia umana, Università di Bologna, Italy.

PMID: 2170491
DOI: 10.1016/0165-1838(90)90092-w

Abstract

In the rat anterior hypothalamic-preoptic region adenosine 3':5'-cyclic monophosphate concentration changes during the ultradian wake-sleep cycle. The administration of DL-propranolol and the exposure to low ambient temperature decreased the nucleotide concentration and also modified the wake-sleep cycle. This suggests that in this region a biochemical correlation exists with different functional states.

MeSH terms

Activity Cycles* / drug effects
Animals
Cyclic AMP / metabolism*
Hypothalamus, Anterior / drug effects
Hypothalamus, Anterior / physiology*
Male
Preoptic Area / drug effects
Preoptic Area / physiology*
Propranolol / pharmacology
Rats
Rats, Inbred Strains
Reference Values
Sleep* / drug effects
Temperature
Wakefulness / drug effects

Substances

Propranolol
Cyclic AMP