Study on preparation of β-cyclodextrin encapsulation tea extract

Int J Biol Macromol. 2011 Nov 1;49(4):561-6. doi: 10.1016/j.ijbiomac.2011.06.013. Epub 2011 Jun 17.

Abstract

Microencapsulation of ethanol extract of tea was performed in this study. In order to microencapsulate, β-cyclodextrin was used as wall material. Ethanol extract of tea was used as the core material. Microcapsules in the solid form were obtained by drying the emulsions. RSM showed that optimal processing parameters were as followings: core material/wall material 1/4, β-cyclodextrin content 16%, stirring time 30 min and stirring temperature 200°C. Pharmacological activities of β-cyclodextrin encapsulation tea extract were determined. It was found that β-cyclodextrin encapsulation tea extract could enhance BMD, BMC and bone Ca, Zn and Cu contents. In addition, β-cyclodextrin encapsulation tea extract could still reduce blood Ca contents. These results indicated that β-cyclodextrin encapsulation tea extract was useful for improving bone quality in aged animals.

MeSH terms

  • Animals
  • Bone Density / drug effects
  • Calcium / metabolism
  • Chromatography, High Pressure Liquid
  • Copper / metabolism
  • Drug Compounding / methods*
  • Ethanol
  • Least-Squares Analysis
  • Mice
  • Plant Extracts / chemical synthesis*
  • Plant Extracts / pharmacology
  • Spectrophotometry, Ultraviolet
  • Tea / chemistry*
  • Zinc / metabolism
  • beta-Cyclodextrins / chemical synthesis*
  • beta-Cyclodextrins / pharmacology

Substances

  • Plant Extracts
  • Tea
  • beta-Cyclodextrins
  • Ethanol
  • Copper
  • Zinc
  • betadex
  • Calcium