Abstract
Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.
Trial registration:
ClinicalTrials.gov NCT00151411.
Copyright © 2011. Published by Elsevier Inc.
Publication types
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Multicenter Study
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Biomarkers / blood
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Caloric Restriction
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Combined Modality Therapy
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Double-Blind Method
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Exercise Therapy
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Female
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Humans
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Metformin / adverse effects
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Metformin / therapeutic use*
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Pilot Projects
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Polycystic Ovary Syndrome / blood
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Polycystic Ovary Syndrome / psychology
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Polycystic Ovary Syndrome / therapy*
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Quality of Life
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Regression Analysis
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Risk Assessment
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Risk Factors
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Risk Reduction Behavior*
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Testosterone / blood
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Time Factors
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Treatment Outcome
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United States
Substances
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Biomarkers
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Testosterone
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Metformin
Associated data
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ClinicalTrials.gov/NCT00151411