Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study

Fertil Steril. 2011 Jun 30;95(8):2595-8.e1-6. doi: 10.1016/j.fertnstert.2011.05.048.

Abstract

Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.

Trial registration: ClinicalTrials.gov NCT00151411.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Biomarkers / blood
  • Caloric Restriction
  • Combined Modality Therapy
  • Double-Blind Method
  • Exercise Therapy
  • Female
  • Humans
  • Metformin / adverse effects
  • Metformin / therapeutic use*
  • Pilot Projects
  • Polycystic Ovary Syndrome / blood
  • Polycystic Ovary Syndrome / psychology
  • Polycystic Ovary Syndrome / therapy*
  • Quality of Life
  • Regression Analysis
  • Risk Assessment
  • Risk Factors
  • Risk Reduction Behavior*
  • Testosterone / blood
  • Time Factors
  • Treatment Outcome
  • United States

Substances

  • Biomarkers
  • Testosterone
  • Metformin

Associated data

  • ClinicalTrials.gov/NCT00151411