The treatment of early breast cancer in women over the age of 70

Br J Cancer. 2011 Jul 12;105(2):189-93. doi: 10.1038/bjc.2011.234. Epub 2011 Jun 21.

Abstract

One third of all breast cancers are diagnosed in women aged 70 or over. Older women are a heterogeneous population who are under-represented in clinical trials, and as a result uncertainty can exist as to what represents optimal treatment. This minireview, from an international authorship, summarises the existing evidence surrounding the management of early breast cancer in women aged 70 and over. The use of primary surgery and endocrine therapy, and adjuvant chemotherapy, radiotherapy, endocrine therapy and trastuzumab are discussed. Reference is made to ongoing clinical trials in this area and areas of controversy are highlighted.

Publication types

  • Evaluation Study
  • Review

MeSH terms

  • Age Factors
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Carcinoma / epidemiology
  • Carcinoma / pathology
  • Carcinoma / therapy*
  • Combined Modality Therapy
  • Female
  • Humans
  • Mastectomy / methods
  • Neoadjuvant Therapy
  • Neoplasm Staging