Ru/Me-BIPAM-catalyzed asymmetric addition of arylboronic acids to aliphatic aldehydes and α-ketoesters

Molecules. 2011 Jun 17;16(6):5020-34. doi: 10.3390/molecules16065020.

Abstract

A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Boronic Acids / chemistry*
  • Catalysis
  • Esters / chemistry*
  • Ketones / chemistry*
  • Ligands
  • Organophosphorus Compounds / chemistry
  • Ruthenium / chemistry*

Substances

  • Aldehydes
  • Boronic Acids
  • Esters
  • Ketones
  • Ligands
  • Organophosphorus Compounds
  • phosphoramidite
  • Ruthenium