Abstract
A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivities.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aldehydes / chemistry*
-
Boronic Acids / chemistry*
-
Catalysis
-
Esters / chemistry*
-
Ketones / chemistry*
-
Ligands
-
Organophosphorus Compounds / chemistry
-
Ruthenium / chemistry*
Substances
-
Aldehydes
-
Boronic Acids
-
Esters
-
Ketones
-
Ligands
-
Organophosphorus Compounds
-
phosphoramidite
-
Ruthenium