This Letter presents simulation and experimental results of orientation-dependent transverse stress fiber sensors using fiber Bragg gratings (FBGs) inscribed in four-hole suspended-core fibers. Resonant peak shifts and splitting of FBGs were studied as functions of the applied transverse load and fiber orientation. Both simulation and experimental results revealed that the response of FBGs in suspended-core fibers is sensitive to both the orientation and magnitude of an applied transverse stress.