Abstract
A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy]ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Validation Study
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Anti-HIV Agents / chemistry*
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Anti-HIV Agents / metabolism
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Anti-HIV Agents / pharmacology*
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Binding Sites
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Computer Simulation
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Drug Design
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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HIV Reverse Transcriptase / antagonists & inhibitors
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HIV Reverse Transcriptase / chemistry
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HIV Reverse Transcriptase / metabolism
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HIV-1 / enzymology
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Imidazoles / chemistry*
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Imidazoles / metabolism
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Imidazoles / pharmacology*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
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Nitroimidazoles / chemistry
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Nitroimidazoles / metabolism
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Nitroimidazoles / pharmacology
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Protein Binding
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / metabolism
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Reverse Transcriptase Inhibitors / pharmacology
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Structure-Activity Relationship
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Transition Temperature
Substances
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Anti-Bacterial Agents
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Anti-HIV Agents
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Imidazoles
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Nitroimidazoles
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Reverse Transcriptase Inhibitors
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reverse transcriptase, Human immunodeficiency virus 1
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HIV Reverse Transcriptase