Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

Acta Pharm. 2011 Jun;61(2):187-201. doi: 10.2478/v10007-011-0018-2.

Abstract

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy]ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / metabolism
  • Anti-HIV Agents / pharmacology*
  • Binding Sites
  • Computer Simulation
  • Drug Design
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • HIV Reverse Transcriptase / antagonists & inhibitors
  • HIV Reverse Transcriptase / chemistry
  • HIV Reverse Transcriptase / metabolism
  • HIV-1 / enzymology
  • Imidazoles / chemistry*
  • Imidazoles / metabolism
  • Imidazoles / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Conformation
  • Nitroimidazoles / chemistry
  • Nitroimidazoles / metabolism
  • Nitroimidazoles / pharmacology
  • Protein Binding
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / metabolism
  • Reverse Transcriptase Inhibitors / pharmacology
  • Structure-Activity Relationship
  • Transition Temperature

Substances

  • Anti-Bacterial Agents
  • Anti-HIV Agents
  • Imidazoles
  • Nitroimidazoles
  • Reverse Transcriptase Inhibitors
  • reverse transcriptase, Human immunodeficiency virus 1
  • HIV Reverse Transcriptase