Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Cell Signal. 2011 Oct;23(10):1546-54. doi: 10.1016/j.cellsig.2011.05.022. Epub 2011 Jun 13.

Abstract

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • GTPase-Activating Proteins / metabolism
  • Glucose / metabolism
  • Glucose Transporter Type 4 / metabolism*
  • Guanine Nucleotide Dissociation Inhibitors / metabolism
  • Humans
  • Insulin / metabolism*
  • Insulin Resistance
  • Muscle Cells / metabolism
  • Muscle, Skeletal / metabolism*
  • Phosphorylation
  • Protein Transport
  • Signal Transduction*
  • rac1 GTP-Binding Protein / metabolism*
  • rho-Specific Guanine Nucleotide Dissociation Inhibitors

Substances

  • Actins
  • GTPase-Activating Proteins
  • Glucose Transporter Type 4
  • Guanine Nucleotide Dissociation Inhibitors
  • Insulin
  • RAC1 protein, human
  • SLC2A4 protein, human
  • rho-Specific Guanine Nucleotide Dissociation Inhibitors
  • rac1 GTP-Binding Protein
  • Glucose