Two-photon induced responsive f-f emissive detection of Cyclin A with a europium-chelating peptide

Hoi-Kwan Kong; Frances L Chadbourne; Ga-Lai Law; Hongguang Li; Hoi-Lam Tam; Steven L Cobb; Chi-Kong Lau; Chi-Sing Lee; Ka-Leung Wong

doi:10.1039/c1cc12811f

Two-photon induced responsive f-f emissive detection of Cyclin A with a europium-chelating peptide

Chem Commun (Camb). 2011 Jul 28;47(28):8052-4. doi: 10.1039/c1cc12811f. Epub 2011 Jun 16.

Authors

Hoi-Kwan Kong¹, Frances L Chadbourne, Ga-Lai Law, Hongguang Li, Hoi-Lam Tam, Steven L Cobb, Chi-Kong Lau, Chi-Sing Lee, Ka-Leung Wong

Affiliation

¹ Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR.

PMID: 21681288
DOI: 10.1039/c1cc12811f

Abstract

Responsive linear and two-photon induced europium emissive probes have been synthesised with a tailor made peptide for the detection of Cyclin A, the hypersensitive Eu emission (Eu-2) gave the real time signalling and also enhanced the two-photon absorption cross section from 12 GM to 68 GM after Cyclin A binding.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorption
Chelating Agents / chemistry*
Cyclin A / chemistry*
Europium / chemistry*
HeLa Cells
Humans
Luminescent Measurements
Molecular Imaging
Photons*

Substances

Chelating Agents
Cyclin A
Europium