Abstract
Selectins form a family of Ca2+ -dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising therapeutic approach to treat acute and chronic inflammatory diseases which are caused by excessive extravasation of leukocytes. This mini-review highlights the major structural differences between E- and P-selectin and summarizes the resulting strategies for the design of selectin antagonists.
MeSH terms
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Anti-Inflammatory Agents / pharmacology
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Cell Adhesion / drug effects
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Drug Design
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E-Selectin / chemistry*
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E-Selectin / metabolism
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Inflammation / drug therapy
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Inflammation / metabolism
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Leukocytes / metabolism
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Membrane Glycoproteins / chemistry*
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Membrane Glycoproteins / metabolism
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Models, Molecular
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Oligosaccharides / chemistry*
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Oligosaccharides / metabolism
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P-Selectin* / antagonists & inhibitors
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P-Selectin* / chemistry
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P-Selectin* / metabolism
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Protein Binding / drug effects
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Sialyl Lewis X Antigen
Substances
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Anti-Inflammatory Agents
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E-Selectin
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Membrane Glycoproteins
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Oligosaccharides
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P-Selectin
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P-selectin ligand protein
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Sialyl Lewis X Antigen