Role and regulation of bacterial LuxR-like regulators

J Cell Biochem. 2011 Oct;112(10):2694-702. doi: 10.1002/jcb.23219.

Abstract

LuxR transcriptional regulator is a key player in Quorum Sensing (QS), coordinates the expression of a variety of genes, including those encoding virulence factors and antibiotics biosynthesis, motility, nodulation, plasmid transfer, bioluminescence, and biofilm formation. The characteristics and roles of this family, especially those of Mycobacterium, are summarized in this paper to give clues for drug target discovery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression Regulation, Bacterial*
  • Mycobacterium / genetics
  • Mycobacterium / metabolism
  • Quorum Sensing / genetics
  • Quorum Sensing / physiology
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*

Substances

  • Bacterial Proteins
  • Repressor Proteins
  • Trans-Activators
  • LuxR autoinducer binding proteins