Abstract
Helicobacter pylori (H. pylori) infection is among the most common human infections and the major risk factor for peptic ulcer disease and gastric cancer. Within this work we present the implication of C-terminal region of H. pylori neutrophil activating protein in the stimulation of neutrophil activation as well as the evidence that the C-terminal region of H. pylori activating protein is indispensable for neutrophil adhesion to endothelial cells, a step necessary to H. pylori inflammation. In addition we show that arabino galactan proteins derived from chios mastic gum, the natural resin of the plant Pistacia lentiscus var. Chia inhibit neutrophil activation in vitro.
Keywords:
Gastric cancer; Helicobacter pylori; Helicobacter pylori neutrophil activating protein; Peptic ulcer disease.
Publication types
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Editorial
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Endothelial Cells / cytology
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Endothelial Cells / metabolism
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Helicobacter Infections / drug therapy*
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Helicobacter pylori / metabolism*
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Humans
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Inflammation / drug therapy*
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Inflammation / microbiology
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Mastic Resin
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Models, Molecular
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Molecular Sequence Data
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Neutrophil Activation / drug effects
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Neutrophils / cytology
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Neutrophils / drug effects
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Neutrophils / immunology
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Pistacia / chemistry
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Protein Conformation
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Resins, Plant / chemistry
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Resins, Plant / pharmacology
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Resins, Plant / therapeutic use*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Mastic Resin
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Resins, Plant
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neutrophil-activating protein A, Helicobacter pylori