Abstract
Isomalyngamide A (1) and A-1 (2) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3-9), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to micromolar ranges, perhaps, by inactivating the expression of p-FAK, FAK, p-Akt and Akt through β1 integrin-mediated antimetastatic pathway.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry
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Amides / pharmacology*
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Blotting, Western
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Cell Line, Tumor
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Cell Movement / drug effects*
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Focal Adhesion Protein-Tyrosine Kinases / metabolism
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Humans
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Integrin beta1 / metabolism
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Magnetic Resonance Spectroscopy
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Neoplasm Metastasis / prevention & control
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Neoplasms / enzymology
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Neoplasms / metabolism
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Neoplasms / pathology*
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Proto-Oncogene Proteins c-akt / metabolism
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Pyrroles / chemistry
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Pyrroles / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
Substances
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Amides
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Integrin beta1
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Pyrroles
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isomalyngamide A
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Focal Adhesion Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-akt