Abstract
A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4' of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / drug therapy
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Alzheimer Disease / pathology
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Animals
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Cell Line
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Humans
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Microscopy, Phase-Contrast
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Molecular Mimicry
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Nerve Growth Factor / pharmacology
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Neurites / drug effects*
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Neurons / cytology
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Neurons / drug effects*
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Ophiopogon / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Roots / chemistry
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Rats
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Saponins / chemistry
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Saponins / pharmacology*
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Structure-Activity Relationship
Substances
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Plant Extracts
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Saponins
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Nerve Growth Factor