Infection with adeno-associated virus type 5 inhibits mutagenicity of herpes simplex virus type 1 or 4-nitroquinoline-1-oxide

Mutat Res. 1990 Aug;244(4):317-20. doi: 10.1016/0165-7992(90)90079-y.

Abstract

Infection with adeno-associated virus type 5 (AAV-5) reduced the number of mutants arising in the hypoxanthine phosphoribosyltransferase locus of human RD 176 cells after infection with herpes simplex virus type 1 (HSV-1; partially inactivated) or 4-nitroquinoline-1-oxide (4-NQO). The mutation frequency was reduced by AAV-5 infection from 11.4 to 1.8 after mutation with HSV-1 and from 3.2 to 2.5 when mutation was induced by 4-NQO. This was analyzed by determination of the number of cells resistant to 8-azaguanine when infected with AAV-5 prior to induction of mutations with HSV-1 or 4-NQO.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Nitroquinoline-1-oxide / toxicity*
  • Azaguanine / pharmacology
  • Dependovirus / physiology*
  • Drug Resistance
  • Humans
  • Hypoxanthine Phosphoribosyltransferase / genetics*
  • Hypoxanthine Phosphoribosyltransferase / metabolism
  • Mutagenicity Tests
  • Mutation
  • Nitroquinolines / toxicity*
  • Simplexvirus / physiology*
  • Tumor Cells, Cultured
  • Virus Replication

Substances

  • Nitroquinolines
  • 4-Nitroquinoline-1-oxide
  • Hypoxanthine Phosphoribosyltransferase
  • Azaguanine