A rapid, four-component synthesis of functionalized thiazoles

Comb Chem High Throughput Screen. 2011 Nov;14(9):824-8. doi: 10.2174/138620711796957134.

Abstract

An efficient synthesis of 2-(dialkylamino)-4-phenyl)-1,3-thiazol-5-yl)(phenyl)methanone using acid chlorides, secondary amines, 2-bromoacethophenone and ammonium thiocyanate is described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Magnetic Resonance Spectroscopy
  • Spectrophotometry, Infrared
  • Thiazoles / chemical synthesis*
  • Thiazoles / pharmacology

Substances

  • Thiazoles