Abstract
Many Ru and Os systems display photoactive (3)MLCT states. Systems activated by therapeutic window light in the absence of O(2) remain elusive. [(bpy)(2)Os(dpp)RhCl(2)(phen)](3+) photobinds and photocleaves DNA under red light in an oxygen independent manner, due to molecular design involving one Os chromophore coupled to a photoactive cis-Rh(III)Cl(2) moiety.
MeSH terms
-
Color
-
DNA / chemistry*
-
DNA / metabolism
-
DNA Cleavage / drug effects
-
DNA Cleavage / radiation effects*
-
Electron Transport
-
Light*
-
Organometallic Compounds / chemistry*
-
Organometallic Compounds / metabolism
-
Organometallic Compounds / pharmacology*
-
Osmium / chemistry
-
Oxygen / chemistry
-
Photochemical Processes / drug effects
-
Photochemical Processes / radiation effects*
-
Photosensitizing Agents / chemistry
-
Photosensitizing Agents / metabolism
-
Photosensitizing Agents / pharmacology
-
Rhodium / chemistry
Substances
-
Organometallic Compounds
-
Photosensitizing Agents
-
Osmium
-
DNA
-
Rhodium
-
Oxygen