Abstract
Cancer development involves multiple genetic changes, which can occur in tumor suppressor genes and lead to loss of function in a recessive manner. Recent findings have identified a novel tumor suppressor gene named GRIM-19. Similar to what has been observed for other known tumor suppressor proteins such as p53, GRIM-19 gene mutations and loss of protein expression have been observed in several tumor types. In this review, we perform a detailed description on the current understanding of GRIM-19 function in carcinogenesis.
Copyright © 2011 Elsevier B.V. All rights reserved.
MeSH terms
-
Animals
-
Apoptosis Regulatory Proteins / genetics
-
Apoptosis Regulatory Proteins / metabolism*
-
Cell Transformation, Neoplastic / metabolism*
-
Cyclin-Dependent Kinase Inhibitor p16 / metabolism
-
Electron Transport
-
Gene Expression
-
Granulocyte Colony-Stimulating Factor / metabolism
-
Humans
-
Mitochondrial Proteins / genetics
-
Mitochondrial Proteins / metabolism*
-
NADH, NADPH Oxidoreductases / genetics
-
NADH, NADPH Oxidoreductases / metabolism*
-
Neoplasms / metabolism*
-
Neoplasms / pathology
-
STAT3 Transcription Factor / metabolism
Substances
-
Apoptosis Regulatory Proteins
-
Cyclin-Dependent Kinase Inhibitor p16
-
Mitochondrial Proteins
-
OLFM4 protein, human
-
STAT3 Transcription Factor
-
Granulocyte Colony-Stimulating Factor
-
NADH, NADPH Oxidoreductases
-
NDUFA13 protein, human