Single-cell-level microplasma cancer therapy

Jae Young Kim; Yanzhang Wei; Jinhua Li; Paul Foy; Thomas Hawkins; John Ballato; Sung-O Kim

doi:10.1002/smll.201100456

Single-cell-level microplasma cancer therapy

Small. 2011 Aug 22;7(16):2291-5. doi: 10.1002/smll.201100456. Epub 2011 Jun 10.

Authors

Jae Young Kim¹, Yanzhang Wei, Jinhua Li, Paul Foy, Thomas Hawkins, John Ballato, Sung-O Kim

Affiliation

¹ Holcombe Department of Electrical and Computer Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA.

PMID: 21661106
DOI: 10.1002/smll.201100456

Abstract

A flexible microplasma endoscope based on a 15 μm hollow-core glass optical fiber is fabricated, and tumor cell apoptotic analysis supports its potential use in targeted cancer therapies. The optical-fiber microplasma jet reveals antitumor activity at a certain plasma dose in animal studies.

Keywords: antitumor agents; cancer therapy; microplasma jets; optical fibers; plasma medicine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Endoscopes*
Equipment Design
Equipment Failure Analysis
Fiber Optic Technology / instrumentation*
Melanoma / pathology*
Melanoma / therapy*
Mice
Microinjections / instrumentation*
Plasma Gases / administration & dosage*
Treatment Outcome

Substances

Plasma Gases