Site-selective labeling at Cys302 of aldehyde dehydrogenase unveils a selective mitochondrial stain

Mol Biosyst. 2011 Aug;7(8):2375-8. doi: 10.1039/c1mb05137g. Epub 2011 Jun 9.

Abstract

A mitochondria-trackable fluorophore, CDy2, selectively labels Cys302 in the active site of mitochondrial aldehyde dehydrogenase (ALDH2).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Affinity Labels / chemistry
  • Affinity Labels / metabolism
  • Aldehyde Dehydrogenase / chemistry*
  • Aldehyde Dehydrogenase / genetics
  • Aldehyde Dehydrogenase / metabolism
  • Binding Sites
  • Cysteine / chemistry
  • Cysteine / metabolism*
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / metabolism
  • HEK293 Cells
  • Heterocyclic Compounds, 3-Ring / chemistry*
  • Heterocyclic Compounds, 3-Ring / metabolism
  • Humans
  • Mitochondria / metabolism*
  • Mutagenesis, Site-Directed
  • Piperidines / chemistry*
  • Piperidines / metabolism

Substances

  • Affinity Labels
  • CDy2 compound
  • Fluorescent Dyes
  • Heterocyclic Compounds, 3-Ring
  • Piperidines
  • Aldehyde Dehydrogenase
  • Cysteine