In this paper, we present a simple and effective scene-based nonuniformity correction (NUC) method for infrared focal plane arrays based on interframe registration. This method estimates the global translation between two adjacent frames and minimizes the mean square error between the two properly registered images to make any two detectors with the same scene produce the same output value. In this way, the accumulation of the registration error can be avoided and the NUC can be achieved. The advantages of the proposed algorithm lie in its low computational complexity and storage requirements and ability to capture temporal drifts in the nonuniformity parameters. The performance of the proposed technique is thoroughly studied with infrared image sequences with simulated nonuniformity and infrared imagery with real nonuniformity. It shows a significantly fast and reliable fixed-pattern noise reduction and obtains an effective frame-by-frame adaptive estimation of each detector's gain and offset.