Abstract
Ypd1 is a key phosphorelay protein that controls eukaryotic two-component systems, but its function in Cryptococcus neoformans is not known. Here, we report that Ypd1 is required for the viability of C. neoformans via the Hog1 mitogen-activated protein kinase (MAPK) pathway but plays multiple cellular roles in both a Hog1-dependent and -independent manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Cryptococcus neoformans / genetics
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Cryptococcus neoformans / metabolism*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Gene Knockout Techniques
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Intracellular Signaling Peptides and Proteins / metabolism
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Mitogen-Activated Protein Kinases / metabolism
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Phosphotransferases / genetics*
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Phosphotransferases / metabolism
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Protein Kinases / genetics*
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Protein Kinases / metabolism
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Sequence Alignment
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Sequence Analysis, DNA
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Signal Transduction
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Stress, Physiological*
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Virulence Factors / metabolism*
Substances
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Fungal Proteins
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Intracellular Signaling Peptides and Proteins
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Virulence Factors
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Phosphotransferases
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Protein Kinases
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Mitogen-Activated Protein Kinases