Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans

Eukaryot Cell. 2011 Jul;10(7):998-1002. doi: 10.1128/EC.05124-11. Epub 2011 Jun 3.

Abstract

Ypd1 is a key phosphorelay protein that controls eukaryotic two-component systems, but its function in Cryptococcus neoformans is not known. Here, we report that Ypd1 is required for the viability of C. neoformans via the Hog1 mitogen-activated protein kinase (MAPK) pathway but plays multiple cellular roles in both a Hog1-dependent and -independent manner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cryptococcus neoformans / genetics
  • Cryptococcus neoformans / metabolism*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Knockout Techniques
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mitogen-Activated Protein Kinases / metabolism
  • Phosphotransferases / genetics*
  • Phosphotransferases / metabolism
  • Protein Kinases / genetics*
  • Protein Kinases / metabolism
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Signal Transduction
  • Stress, Physiological*
  • Virulence Factors / metabolism*

Substances

  • Fungal Proteins
  • Intracellular Signaling Peptides and Proteins
  • Virulence Factors
  • Phosphotransferases
  • Protein Kinases
  • Mitogen-Activated Protein Kinases