Abstract
An investigation of the ethanolic extract from stems of Caesalpinia echinata Lam (Leguminosae-Caesalpinioideae) led to the isolation of five new cassane diterpenes along with known lambertianic acid. Their structures were determined based on spectroscopic methods. A preliminary study on leishmanicidal activity demonstrated that compounds 1, 2 and 6 were found to inhibit the growth of amastigote-like forms of Leishmania amazonensis without affecting mononuclear cells obtained from human peripheral blood.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Caesalpinia / chemistry*
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Carboxylic Acids / chemistry
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Carboxylic Acids / isolation & purification
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Carboxylic Acids / pharmacology*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Leishmania / drug effects
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Leukocytes, Mononuclear / drug effects
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification
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Naphthalenes / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Stems
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / isolation & purification
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Trypanocidal Agents / pharmacology*
Substances
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Carboxylic Acids
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Diterpenes
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Naphthalenes
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Plant Extracts
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Trypanocidal Agents
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lambertianic acid