Fine tuning our cellular factories: sirtuins in mitochondrial biology

Cell Metab. 2011 Jun 8;13(6):621-6. doi: 10.1016/j.cmet.2011.05.004.

Abstract

Sirtuins have emerged in recent years as critical regulators of metabolism, influencing numerous facets of energy and nutrient homeostasis. Here, we review recent advances on the role of this fascinating family of mammalian proteins and their well-orchestrated function in modulating mitochondrial activity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetates / metabolism
  • Animals
  • Apoptosis
  • Citric Acid Cycle
  • Electron Transport
  • Glycolysis
  • Humans
  • Insulin / metabolism
  • Lipid Metabolism
  • Liver / metabolism
  • Mitochondria / metabolism*
  • Muscle, Skeletal / metabolism
  • Oxidative Stress
  • Signal Transduction
  • Sirtuins / metabolism*

Substances

  • Acetates
  • Insulin
  • Sirtuins