A radical role for TOR in longevity

Dudley W Lamming; David M Sabatini

doi:10.1016/j.cmet.2011.05.006

A radical role for TOR in longevity

Cell Metab. 2011 Jun 8;13(6):617-8. doi: 10.1016/j.cmet.2011.05.006.

Authors

Dudley W Lamming¹, David M Sabatini

Affiliation

¹ Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

TOR (target of rapamycin) signaling regulates life span in many organisms, but the mechanism behind the effect is unknown. In this issue of Cell Metabolism, Pan and colleagues (2011) find that reduced TORC1 activity promotes yeast life span via a mechanism that, paradoxically, relies upon the production of normally deleterious reactive oxygen species.

Publication types

Comment

Abstract

Publication types

Grants and funding