Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells

Chem Commun (Camb). 2011 Jul 14;47(26):7347-9. doi: 10.1039/c1cc11853f. Epub 2011 Jun 2.

Abstract

Image and spectral intensity from bicarbonate-selective europium(III) probes localised in the mitochondria of cells is modulated reversibly by variation of external pCO(2), and is suppressed by addition of the carbonic anhydrase inhibitor, acetazolomide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bicarbonates / metabolism*
  • Biological Transport
  • Cell Line
  • Cell Survival
  • Humans
  • Microscopy
  • Mitochondria / metabolism*
  • Optical Phenomena*

Substances

  • Bicarbonates