Peripheral nerve involvement in ataxia telangiectasia: histological and ultrastructural studies of peroneal nerve biopsy in two cases

Clin Neuropathol. 1990 May-Jun;9(3):109-14.

Abstract

The authors report a histological and electron-microscopic study of the peripheral nerve in two cases of ataxia-telangiectasia showing fiber loss, storage material in Schwann cells and nuclear changes. Nuclear changes are the most typical finding and are correlated with the primary metabolic disorder of DNA repair.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ataxia / complications*
  • Biopsy
  • Child
  • Female
  • Humans
  • Male
  • Peripheral Nervous System Diseases / etiology*
  • Peripheral Nervous System Diseases / pathology
  • Peroneal Nerve / pathology
  • Syndrome
  • Telangiectasis / complications*