Abstract
Eight new sesquiterpene alkaloids (1-8) and four known sesquiterpene alkaloids (9-12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification*
-
Alkaloids / pharmacology*
-
Antimalarials / chemistry
-
Antimalarials / isolation & purification*
-
Antimalarials / pharmacology*
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Crystallography, X-Ray
-
Drug Screening Assays, Antitumor
-
Maytenus / chemistry*
-
Molecular Structure
-
Plasmodium falciparum / drug effects*
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / pharmacology*
-
Thailand
Substances
-
Alkaloids
-
Antimalarials
-
Antineoplastic Agents, Phytogenic
-
Sesquiterpenes