Mean-squared atomic displacements in hydrated lysozyme, native and denatured

J Biol Phys. 2010 Jun;36(3):291-7. doi: 10.1007/s10867-009-9184-6. Epub 2010 Jan 13.

Abstract

We use elastic neutron scattering to demonstrate that a sharp increase in the mean-squared atomic displacements, commonly observed in hydrated proteins above 200 K and often referred to as the dynamical transition, is present in the hydrated state of both native and denatured lysozyme. A direct comparison of the native and denatured protein thus confirms that the presence of the transition in the mean-squared atomic displacements is not specific to biologically functional molecules.

Keywords: Biomolecules; Dynamics; Neutron scattering.