Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra

Yusnita Rifai; Midori A Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi

doi:10.1007/s11418-011-0530-1

Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra

J Nat Med. 2011 Jul;65(3-4):629-32. doi: 10.1007/s11418-011-0530-1. Epub 2011 Apr 6.

Authors

Yusnita Rifai¹, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

PMID: 21625949
DOI: 10.1007/s11418-011-0530-1

Abstract

Complete (1)H and (13)C NMR assignments of acoschimperoside P, 2'-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apocynaceae / chemistry*
Blotting, Western
Cardiac Glycosides / chemistry
Cardiac Glycosides / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Glycosides / chemistry
Glycosides / pharmacology*
Humans
Molecular Structure

Substances

Cardiac Glycosides
Glycosides