Facile functionalization of polypeptides by thiol-yne photochemistry for biomimetic materials synthesis

Chem Commun (Camb). 2011 Jul 14;47(26):7509-11. doi: 10.1039/c1cc12177d. Epub 2011 May 31.

Abstract

Rapid and highly efficient side-chain functionalization of polypeptides was achieved via combination of ring-opening polymerization of a new clickable monomer of γ-propargyl-L-glutamate N-carboxyanhydride (PLG-NCA) and thiol-yne photochemistry, which provides a convenient and universal route to prepare diverse polypeptide-based biomimetic hybrid materials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Biomimetic Materials / chemical synthesis*
  • Biomimetic Materials / chemistry*
  • Glutamic Acid / chemistry
  • Hydrophobic and Hydrophilic Interactions
  • Kinetics
  • Peptides / chemistry*
  • Photochemical Processes*
  • Polymerization
  • Sulfhydryl Compounds / chemistry*

Substances

  • Alkynes
  • Peptides
  • Sulfhydryl Compounds
  • Glutamic Acid