Epigenetic modifications in distinction: histone versus DNA methylation in ESCs

Kevin Huang; Guoping Fan

doi:10.1016/j.stem.2011.05.007

Epigenetic modifications in distinction: histone versus DNA methylation in ESCs

Cell Stem Cell. 2011 Jun 3;8(6):604-5. doi: 10.1016/j.stem.2011.05.007.

Authors

Kevin Huang¹, Guoping Fan

Affiliation

¹ Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7088, USA.

PMID: 21624801
DOI: 10.1016/j.stem.2011.05.007

Abstract

In this issue of Cell Stem Cell, Karimi et al. (2011) show that DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) have distinct genomic targets in mouse ESCs. In particular, loss of H3K9me3 leads to derepression of select endogenous retroviruses and subsequent ectopic transcription of adjacent genes.

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