Value of β2-microglobulin in the serum of healthy subjects older than 40 years

Abstract

The aim of this research was to determine if the age of healthy subjects older than 40 years of age has an influence on the concentration of β(2) -microglobulin in the serum of subjects of different populations. We examined the values of β(2) -microglobulin in the serum of 51 healthy subjects aged 40-86 years using the microparticle enzyme immunoassay AxSYM β(2) -microglobulin test. The reference values of β(2) -microglobulin according to the nonparametric statistical method is 0.95-2.73 mg/L. A correlation was found between β(2) -microglobulin and age: 40-50 years (0.94-1.54 mg/L), 51-65 years (0.96-2.62 mg/L), and >65 years (1.13-2.84 mg/L). There was no significant statistical difference of β(2) -microglobulin between genders (P > 0.05); however, there was a statistically significant difference between the concentration of β(2) -microglobulin and the subjects' age. (Spearman's rank correlation coefficient ρ = 0.66; P < 0.01). A direct correlation between age and the concentration of β(2) -microglobulin was observed. This research is a contribution to determining reference values of β(2) -microglobulin in subjects of different populations.