Abstract
A new furanocoumarin named lucidafuranocoumarin A (7) together with 13 known coumarins (1-6, 8-14) and four known alkaloids (15-18) was isolated from the roots of Feroniella lucida. Their structures were elucidated on the basis of spectroscopic analysis. Some of the isolates were evaluated for their biological activities, and compound 18 showed strong cytotoxicity against KB (IC(50) = 0.637 μg/ml) and NCI-H187 (IC(50) = 0.094 μg/ml) human cancer cell lines, antimalarial activity against Plasmodium falciparum (IC(50) = 0.336 μg/ml), and antituberculosis activity against Mycobacterium tuberculosis (MIC = 6.25 μg/ml).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Humans
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KB Cells
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Plant Roots / chemistry
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Plasmodium falciparum / drug effects*
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Rutaceae / chemistry*
Substances
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Alkaloids
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Antimalarials
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Antineoplastic Agents, Phytogenic
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Antitubercular Agents
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Coumarins
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Furans
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lucidafuranocoumarin A