Abstract
There have been numerous publications linking Ca(2+) signaling and cancer, however, a clear explanation for this link has remained elusive. We recently identified the oncogenes/tumor suppressors Wilms Tumor Suppressor 1 (WT1) and Early Growth Response 1 (EGR1) as regulators of the expression of STIM1, an essential regulator of Ca(2+) entry in non-excitable cells. The current review focuses on the literature defining both differential Ca(2+) signaling and WT1/EGR1 expression patterns in 6 specific cancer subtypes: Acute Myeloid Leukemia, Wilms Tumor, breast cancer, ovarian cancer, glioblastoma and prostate cancer. For each tumor-type, we have assessed how specific changes in WT1 and EGR1 expression might contribute to aberrant Ca(2+) homeostasis as well as the therapeutic potential of these observations.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Brain Neoplasms / genetics
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Brain Neoplasms / metabolism
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism
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Calcium Signaling
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Early Growth Response Protein 1 / genetics
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Early Growth Response Protein 1 / metabolism*
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Female
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Gene Expression Regulation, Neoplastic
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Genes, Tumor Suppressor
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Genes, Wilms Tumor
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Glioblastoma / genetics
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Glioblastoma / metabolism
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Humans
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Leukemia, Myeloid, Acute / genetics
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Leukemia, Myeloid, Acute / metabolism
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Male
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Models, Biological
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Neoplasms / genetics
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Neoplasms / metabolism*
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Oncogenes
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / metabolism
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / metabolism
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Stromal Interaction Molecule 1
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Transient Receptor Potential Channels / metabolism
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WT1 Proteins / metabolism*
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Wilms Tumor / genetics
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Wilms Tumor / metabolism
Substances
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EGR1 protein, human
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Early Growth Response Protein 1
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Membrane Proteins
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Neoplasm Proteins
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Proto-Oncogene Proteins c-bcl-2
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STIM1 protein, human
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Stromal Interaction Molecule 1
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Transient Receptor Potential Channels
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WT1 Proteins