Vascular endothelial growth factor expression up-regulated by endometrial ischemia in secretory phase plays an important role in endometriosis

Fertil Steril. 2011 Jun 30;95(8):2687-9. doi: 10.1016/j.fertnstert.2011.05.001. Epub 2011 May 25.

Abstract

Primary human endometrial cells were exposed to hypoxia preconditioning (HPC), HPC-hypoxia, and hypoxia conditions, and then endometrial tissue treated with ischemia preconditioning (IPC) was transplanted onto the chick embryo chorioallantoic membrane to investigate the role of slight ischemia of endometrium in the pathologic process of endometriosis. IPC up-regulated vascular endothelial growth factor expression and decreased apoptosis of endometrial cells, thus facilitating the endometrial fragments' ectopic implantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Apoptosis
  • Cell Hypoxia
  • Cell Proliferation
  • Cells, Cultured
  • Chick Embryo
  • Chorioallantoic Membrane / blood supply*
  • Constriction
  • Endometriosis / metabolism*
  • Endometriosis / pathology
  • Endometriosis / physiopathology
  • Endometrium / blood supply
  • Endometrium / metabolism*
  • Endometrium / pathology
  • Endometrium / transplantation
  • Female
  • Humans
  • Ischemic Preconditioning / methods*
  • Microvessels / physiopathology
  • Middle Aged
  • Time Factors
  • Up-Regulation
  • Uterine Artery / surgery
  • Vascular Endothelial Growth Factor A / metabolism*

Substances

  • Vascular Endothelial Growth Factor A