Abstract
Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs;'profens'), such as ibuprofen, is important for pharmacological activity. Several 2-APA-CoA esters were good racemisation substrates for human AMACR 1A, suggesting a common chiral inversion pathway for all 2-APAs and an additional mechanism for their anti-cancer properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / metabolism*
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Antineoplastic Agents / pharmacology
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Catalytic Domain
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Esters
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Humans
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Ibuprofen / chemistry*
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Ibuprofen / metabolism*
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Ibuprofen / pharmacology
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Models, Molecular
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Mycobacterium tuberculosis / enzymology
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Protein Binding
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Racemases and Epimerases / chemistry
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Racemases and Epimerases / metabolism*
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Stereoisomerism
Substances
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Antineoplastic Agents
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Esters
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Racemases and Epimerases
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alpha-methylacyl-CoA racemase
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Ibuprofen