Role for proteases and HLA-G in the pathogenicity of influenza A viruses

Marie-Laure Foucault; Vincent Moules; Manuel Rosa-Calatrava; Béatrice Riteau

doi:10.1016/j.jcv.2011.04.013

Role for proteases and HLA-G in the pathogenicity of influenza A viruses

J Clin Virol. 2011 Jul;51(3):155-9. doi: 10.1016/j.jcv.2011.04.013. Epub 2011 May 25.

Authors

Marie-Laure Foucault¹, Vincent Moules, Manuel Rosa-Calatrava, Béatrice Riteau

Affiliation

¹ CNRS FRE 3011 VirPath, Virologie et Pathologie Humaine, Faculté de médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, F-69008 Lyon, France.

PMID: 21612979
DOI: 10.1016/j.jcv.2011.04.013

Abstract

Influenza is one of the most common infectious diseases in humans occurring as seasonal epidemic and sporadic pandemic outbreaks. The ongoing infections of humans with avian H5N1 influenza A viruses (IAV) and the past 2009 pandemic caused by the quadruple human/avian/swine reassortant (H1N1) virus highlights the permanent threat caused by these viruses. This review aims to describe the interaction between the virus and the host, with a particular focus on the role of proteases and HLA-G in the pathogenicity of influenza viruses.

Publication types

Review

MeSH terms

HLA Antigens / immunology*
HLA-G Antigens
Histocompatibility Antigens Class I / immunology*
Host-Pathogen Interactions*
Humans
Immune Evasion
Immune Tolerance
Influenza A virus / immunology*
Influenza A virus / pathogenicity*
Influenza, Human / immunology*
Influenza, Human / virology*
Peptide Hydrolases / metabolism*

Substances

HLA Antigens
HLA-G Antigens
Histocompatibility Antigens Class I
Peptide Hydrolases