Abstract
Chemical investigation of the endophytic fungus Emericella sp. (HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum led to isolation of six isoindolones derivatives termed as emerimidine A and B and emeriphenolicins A and D, and six previously reported compounds named aspernidine A and B, austin, austinol, dehydroaustin, and acetoxydehydroaustin, respectively. Their structures were elucidated on the basis of NMR spectroscopic evidence while the anti-influenza A viral (H₁N₁) activities of eight compounds were also evaluated using the cytopathic effect (CPE) inhibition assay.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Cell Line
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Dogs
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Emericella / chemistry*
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Fermentation
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Influenza A Virus, H1N1 Subtype / drug effects*
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Isoindoles / chemistry
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Isoindoles / isolation & purification
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Isoindoles / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Bark / microbiology
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Primulaceae / microbiology*
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Sesquiterpenes / chemistry
Substances
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Antiviral Agents
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Biological Products
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Isoindol-1-one
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Isoindoles
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Sesquiterpenes
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emerimidine
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emeriphenolicin